What is Endocannabinoid System ?



What is Endocannabinoid System ?

 The endocannabinoid system (ECS) is a biological mechanism in the body that aids in the regulation and balance of vital bodily processes. Endocannabinoid system is found in all human and animal  brains and nervous systems and is the most complex yet crucial biological system of receptors in the body. We know this based on the large amount of research and evidence that surrounds the endocannabinoid system, The most recent research shows that cannabis actively contributes to the growth and function of this system. 


Human Endocannabinoid System :

 Humans are born with an endocannabinoid system that plays a crucial role in brain development as well as the formation and maintenance of synapses, the electrical connections in the brain that allow neurotransmitters to transfer and receive information. Endocannabinoids interact with the receptors in our brain, helping them to activate and function properly.

 Endocannabinoids and receptors coexist throughout the neurological system, glands, immunological cells, organs, the brain, and connective tissues.  What’s more, the endocannabinoid system is crucial to maintaining and creating new neurons, which can be linked to memory, learning and regulating many physiological processes within the body.


Functions :

The system pervades the eleven primary physiological systems in the body, all of which operate to handle the numerous duties required for our existence. It also coordinates and controls activities, such as breathing, growth, digestion and metabolism

The ECS is also responsible for balancing our critical physiological activities, which include sleep, hunger, pain, inflammation, memory, mood, and reproduction and one of the body’s primary pain-balancing systems. The ECS aids in the regulation of homeostasis across all human physiological systems, ensuring that they all operate in peace with one another. The body produces its own natural cannabinoids that modulate biological processes.

 For an example,  stress raises the stress hormone cortisol in your circulation, which increases endocannabinoid synthesis. Endo-cannabinoids rise in response to stress in order to balance cortisol production in the blood. To understand this better, CBD is a normal, endogenous (your body makes it), sedative (relaxant) substance in the human body that modulates biological processes using endogenous cannabinoid receptors.

 The ECS operates in the keylock model cannabinoids act as the keys within the endocannabinoid system, while receptors act like locks.Every time one key fits into one lock the lock causes an effect to occur in the body.

 ECS is made up of three major components:




  1. ANANDAMIDE and 2AG are the two primary forms of endocannabinoids present in the body. 2AG is the most common endocannabinoid that regulates hunger, pain, response, and immune system activities. An Anandamide is responsible for the runner's high and the joyful moods that occur as a result of exercise and meditation.
  1. Enzymes function inside the ECS to recycle spent endocannabinoids when the body has used them up.
  1. Cannabinoids, which are a class of active substances that interact with ECS receptors, send and receive messages to receptors. CB1 and CB2 are the two primary kinds of receptors.

 CB1 receptors are found in the brain and spinal cord and act to control hunger, memory, and pain. CBD2 receptors are found throughout the immune system and operate largely to decrease inflammation throughout the body.

 The endocannabinoid system (ECS) handles diverse activities in different parts of the body, but the ECS always has one aim in mind: equilibrium, aka homeostasis.

 The homeostasis system strives to maintain the body's stability in the face of the necessary changes and fluctuations in the external physical and mental environment.

 This one-of-a kind and evasive mechanism is the cause for medicinal cannabis's clinical application. Now you have an idea about how does your favorite CBD Oil works to reduce your anxiety or serious pain.


Natural Endocannabinoids Vs External Cannabinoids :

 Endocannabinoids are naturally produced within the body. Exogenous cannabinoids are compounds found outside the body, such as CBD and THC.

 CBD and THC are phytocannabinoids, which means they are derived from plants. Exogenous cannabinoids  function similarly to endocannabinoids produced by the body. While our human body lack the ability to produce natural cannabinoids due to lifestyle change, chronic illness, the imbalance can be balanced by using natural cannabinoids from mother nature such as CBD,THC,CBG,Etc..,

 The use of phytocannabinoids to balance the ECS is not new to us. We, as a more advanced species on the planet, have been doing this from ancient times. Using cannabis and hemp to cure our minds and bodies is a centuries-old practise that our Chinese and Indian predecessors were familiar with.


Why do we need CBD or THC when our bodies synthesize them naturally ? 

 Even while our bodies can make ECBs naturally, poor nutrition, lack of exercise, and other factors can disturb ECB production, contributing to biological imbalance and illnesses including chronic inflammation, poor immunological response, depression, and anxiety.

 Much like how we use essential oils to improve the health and smells of our homes, these ancient societies were able to manipulate plants into a functional system that reflected their needs.

 CBD and THC extracts have been administered in oil form to heal human diseases by reversing the natural changes that occur in the human endocannabinoid system.

 Cannabidiol Oil, THC : CBD Combined extracts are examples of potential modern-day remedies. In fact cannabis is the only known plant in the world to actively synthesize anandamide (AEA) which is a chemical that gives us a sense of wellbeing, relaxation and happiness when we have enough.